Washington State University

Zhiquan Shu - Clinical Assistant Professor

The School of Mechanical and Materials Engineering

Zhiquan Shu - Clinical Assistant Professor

Interdisciplinary Excellence Built On World-Class Knowledge

portrait
Zhiquan Shu

Contact Information:

office Gray Wolf Hall 210 Everett
telephone 425 405 1732
e-mail zq.shu@wsu.edu
Postal mail Zhiquan Shu
School of Mechanical and Materials Engineering
Washington State University
PO BOX 642920
Pullman, WA 99164-2920

Joined MME in 2015;
Ph.D. in Mechanical Engineering, University of Washington, 2013.

Everett Address
Zhiquan 'Andy' Shu Ph.D.
School of Mechanical & Materials Engineering
Washington State University, University Center of North Puget Sound
Everett Community College
2000 Tower Street, MS-45
Everett, WA 98201-1390

Research Interests:

  • Bio-heat/mass transfer
  • Cryobiology, biopreservation and biobanking
  • Bio-instruments
  • Microfluidics

Recent Publications:

  • Book chapter--Z Shu, D Gao, and L Pu. “Update on cryopreservation of adipose tissue and adipose derived stem cells”, in “Fat Grafting: Current Concept, Clinical Application, and Regenerative Potential, An Issue of Clinics in Plastic Surgery”, editors: L Pu, K Yoshimura, SR Coleman. Elsevier; (April 2015).
  • Book chapter--Z Shu, Z Huang, S Heimfeld, and D Gao, “Progress in Cryopreservation of Stem Cells and Immune Cells for Cytotherapy”, in "Progress in Stem Cell Transplantation", editor: T Demirer. ISBN 978-953-51-4235-5, in press (2015).
  • X. Liang, PK. Sekar, G Zhao, X Zhou, Z Shu, W Ding, Q Zhang, and D Gao, “High accuracy thermal conductivity determination of semi-rigid biological tissues and aqueous cryoprotective agents using a microfabricated thermal sensor”. Scientific Report, 5, 10377; DOI: 10.1038/srep10377 (2015)
  • S Inoue, A L. Becker, J Kim, Z Shu (equally contributed), S Soelberg, K Weigel, et. al., “Semi-automated, Occupationally Safe Immunofluorescence Microtip Sensor for Point-of-Care Diagnosis of Tuberculosis”, PLoS One, January 22, 2014. DOI: 10.1371/journal.pone.0086018.
  • Z Shu, S Heimfeld, D Gao, “Hematopoietic Stem Cell Transplantation with Cryopreserved Grafts: Adverse Reactions after Transplantation and Cryoprotectant Removal Prior to Infusion”, Bone Marrow Transplantation, 49, 469–476 (2014).
  • Z Shu, K Weigel, S Soelberg, A Lakey, G Cangelosi, K Lee, J Chung, and D Gao, “Cryopreservation of Mycobacterium Tuberculosis Complex Cells”, Journal of Clinical Microbiology, 50(11), 3575-3580, (2012).
  • J Kim, W Yeo, Z Shu, S. Soelberg, S Inoue, D Kalyanasundaram, et. al., “Immunosensor towards low-cost, rapid diagnosis of tuberculosis,” Lab Chip, 2012, 12, 1437.
  • Z Shu , X Kang , H, X Zhou , J Purtteman, D Yadock , S Heimfeld and D Gao, “Development of a reliable low-cost controlled cooling rate instrument for the cryopreservation of hematopoietic stem cells”, Cytotherapy, 12( 2) , 161-169, (2010).

Publications listed at Google Scholar:

57 Titles in date order
List format:
 Title (Link to document)
 Authors
 Source Publication
Cited by Year
Investigation on the thermal performance of a novel microchannel-aided device for vitrification of cells/tissues
X Zhou, Z Shu, XM Liang, C Jiang, Y Su, D Gao
Applied Thermal Engineering , 2017
  2017
Determination of the temperature-dependent cell membrane permeabilities using microfluidics with integrated flow and temperature control
C Fang, F Ji, Z Shu, D Gao
Lab on a Chip 17 (5), 951-960 , 2017
  2017
Quantification of Intracellular Ice Formation and Recrystallization During Freeze–Thaw Cycles and Their Relationship with the Viability of Pig Iliac Endothelium Cells
X Liu, G Zhao, Z Shu, D Niu, Z Zhang, P Zhou, Y Cao, D Gao
Biopreservation and Biobanking 14 (6), 511-519 , 2016
1 2016
Comparative Study on Two Different Methods for Determination of Hydraulic Conductivity of HeLa Cells During Freezing
L Li, C Gao, G Zhao, Z Shu, Y Cao, D Gao
Biopreservation and Biobanking 14 (6), 491-498 , 2016
  2016
Determination of the Membrane Permeability to Water of Human Vaginal Mucosal Immune Cells at Subzero Temperatures Using Differential Scanning Calorimetry
Z Shu, SM Hughes, C Fang, Z Hou, G Zhao, M Fialkow, G Lentz, F Hladik, ...
Biopreservation and biobanking 14 (4), 307-313 , 2016
3 2016
Cryopreservation of human mucosal leukocytes
SM Hughes, Z Shu, CN Levy, AL Ferre, H Hartig, C Fang, G Lentz, ...
PloS one 11 (5), e0156293 , 2016
  2016
A study of the osmotic characteristics, water permeability, and cryoprotectant permeability of human vaginal immune cells
Z Shu, SM Hughes, C Fang, J Huang, B Fu, G Zhao, M Fialkow, G Lentz, ...
Cryobiology 72 (2), 93-99 , 2016
5 2016
Effect of iron oxide nanoparticles on the permeability properties of Sf21 cells
J Wang, G Zhao, Z Shu, P Zhou, Y Cao, D Gao
Cryobiology 72 (1), 21-26 , 2016
  2016
Comparison of the Fitting Validity Between the 2P Model and the Nondilute Solution Model Using Statistical Methods in Modeling Cell Membrane Permeabilities
Y Zhang, G Zhao, J Yi, Z Shu, P Zhou, Y Cao, D Gao
Biopreservation and biobanking 14 (1), 39-44 , 2016
  2016
Sensing and Sensibility: Single‐Islet‐based Quality Control Assay of Cryopreserved Pancreatic Islets with Functionalized Hydrogel Microcapsules
W Chen, Z Shu, D Gao, AQ Shen
Advanced healthcare materials 5 (2), 223-231 , 2016
  2016
High-precision approach based on microfluidic perfusion chamber for quantitative analysis of biophysical properties of cell membrane
W Liu, G Zhao, Z Shu, T Wang, K Zhu, D Gao
International Journal of Heat and Mass Transfer 86, 869-879 , 2015
3 2015
Update on cryopreservation of adipose tissue and adipose-derived stem cells
Z Shu, D Gao, LLQ Pu
Clinics in plastic surgery 42 (2), 209-218 , 2015
9 2015
Progress in Cryopreservation of Stem Cells and Immune Cells for Cytotherapy
Z Shu, S Heimfeld, Z Huang, C Liu, D Gao
Progress in Stem Cell Transplantation , 2015
  2015
Permeation kinetics of dimethyl sulfoxide in human vaginal mucosal tissues
Z Shu, SM Hughes, C Fang, J Pan, G Zhao, F Hladik, D Gao
Cryobiology 3 (71), 559 , 2015
  2015
High accuracy thermal conductivity measurement of aqueous cryoprotective agents and semi-rigid biological tissues using a microfabricated thermal sensor
XM Liang, PK Sekar, G Zhao, X Zhou, Z Shu, Z Huang, W Ding, Q Zhang, ...
Scientific reports 5 , 2015
1 2015
C-2022: Monitoring of the residual cryoprotectant concentration with electrical conductivity measurements during cryoprotectant removal
Z Shu, C Fang, X Zhou, D Liao, F Hladik, D Gao
Cryobiology 69 (3), 521 , 2014
  2014
C-13: Application of hydrogel in cryopreservation as a novel cryoprotectant, encapsulation and single-cell-based functional sensing material
Z Shu, W Chen, AQ Shen, D Gao
Cryobiology 69 (3), 506 , 2014
  2014
C-2017: Cryopreservation of Mycobacterium tuberculosis (MTB) complex cells and sputum specimens for MTB diagnosis
Z Shu, S Inoue, J Kim, K Weigel, A Becker, S Soelberg, G Cangelosi, ...
Cryobiology 69 (3), 520 , 2014
  2014
Cryoprotective Agent (CPA) Removal With Dilution-Filtration Method and CPA Concentration Monitoring With Electrical Conductivity Measurements
Z Shu, C Fang, X Zhou, D Gao
ASME 2014 International Mechanical Engineering Congress and Exposition ... , 2014
  2014
Biotransport and intracellular ice formation phenomena in freezing human embryonic kidney cells (HEK293T)
Y Xu, G Zhao, X Zhou, W Ding, Z Shu, D Gao
Cryobiology 68 (2), 294-302 , 2014
8 2014
Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion
Z Shu, S Heimfeld, D Gao
Bone marrow transplantation 49 (4), 469-476 , 2014
27 2014
Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum
S Inoue, AL Becker, JH Kim, Z Shu, SD Soelberg, KM Weigel, M Hiraiwa, ...
PloS one 9 (1), e86018 , 2014
5 2014
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
LR McKinnon, SM Hughes, SC De Rosa, JA Martinson, J Plants, ...
PloS one 9 (1), e85675 , 2014
21 2014
Heat Transfer and Thermal Engineering
Z Shu, C Fang, X Zhou, D Gao
American Society of Mechanical Engineers (ASME) , 2014
  2014
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
R Kaul, MJ McElrath, JA Passmore, JA Martinson, L Vojtech, S Kimwaki, ...
University of Nairobi , 2014
  2014
Theoretical investigations of a novel microfluidic cooling/warming system for cell vitrification cryopreservation
X Zhou, Z Liu, XM Liang, Z Shu, P Du, D Gao
International Journal of Heat and Mass Transfer 65, 381-388 , 2013
9 2013
Numerical Investigation of a Novel Microfluidic System and its Application in Achieving Ultra-Fast Cooling/Warming Rates for Cell Vitrification Cryopreservation
X Zhou, X Liang, Z Shu, P Du, D Gao
ASME 2013 Summer Bioengineering Conference, V01AT20A005-V01AT20A005 , 2013
  2013
Development of Optimal Biopreservation Methods and Technology for Cellular Therapy and Clinical Diagnosis
Z Shu
University of Washington , 2013
  2013
Cryopreservation of Mycobacterium tuberculosis complex cells
Z Shu, KM Weigel, SD Soelberg, A Lakey, GA Cangelosi, KH Lee, ...
Journal of clinical microbiology 50 (11), 3575-3580 , 2012
10 2012
Immunosensor towards low-cost, rapid diagnosis of tuberculosis
JH Kim, WH Yeo, Z Shu, SD Soelberg, S Inoue, D Kalyanasundaram, ...
Lab on a Chip 12 (8), 1437-1440 , 2012
41 2012
A microfluidic study of megakaryocytes membrane transport properties to water and dimethyl sulfoxide at suprazero and subzero temperatures
HY Tseng, S Sun, Z Shu, W Ding, JA Reems, D Gao
Biopreservation and biobanking 9 (4), 355-362 , 2011
10 2011
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011 (MicroTAS 2011)
CA Launiere, MM Gaskill, JH Myung, S Hong, DT Eddington
15th International Conference on Miniaturized Systems for Chemistry and Life ... , 2011
1 2011
HIGHLY SENSITIVE AND SPECIFIC MICROTIP-IMMUNOFLUORESCENCE SENSOR FOR RAPID TB DIAGNOSIS
JH Kim, WH Yeo, Z Shu, SD Soelberg, S Inoue, D Kalyanasundaram, ...
15th International Conference on Miniaturized Systems for Chemistry and Life ... , 2011
  2011
Microfabricated thermal conductivity sensor: a high resolution tool for quantitative thermal property measurement of biomaterials and solutions
XM Liang, W Ding, H Chen, Z Shu, G Zhao, H Zhang, D Gao
Biomedical microdevices 13 (5), 923-928 , 2011
4 2011
Heat transfer analysis for the design and application of the passive cooling rate controlled device—Box-in-box
X Zhou, Z Shu, W Ding, S Heimfeld, JH Chung, P Du, C Liu, D Gao
International Journal of Heat and Mass Transfer 54 (9), 2136-2143 , 2011
7 2011
A dilution-filtration system for removing cryoprotective agents
X Zhou, Z Liu, Z Shu, W Ding, P Du, JH Chung, C Liu, S Heimfeld, D Gao
Journal of Biomechanical Engineering 133 (2), 021007 , 2011
14 2011
Theoretical and experimental analyses of optimal experimental design for determination of hydraulic conductivity of cell membrane
X Zhou, F Gao, Z Shu, JH Chung, S Heimfeld, D Gao
Biopreservation and biobanking 8 (3), 147-152 , 2010
3 2010
Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
H Hatami-Marbini, PM Pinsky
1st Global Congress on NanoEngineering for Medicine and Biology: Advancing ... , 2010
  2010
Development of a Microfluidic Injection and Perfusion Device for Single Cell Study
HS Chen, Z Shu, L Cheng, D Gao
ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology ... , 2010
  2010
Tip Enrichment System for Rapid Screening of Mycobacterium Tuberculosis
JH Kim, WH Yeo, Z Shu, S Inoue, K Oh, D Gao, JH Chung, KH Lee
ASME 2010 International Mechanical Engineering Congress and Exposition, 273-275 , 2010
1 2010
Development of a reliable low-cost controlled cooling rate instrument for the cryopreservation of hematopoietic stem cells
Z Shu, X Kang, H Chen, X Zhou, J Purtteman, D Yadock, S Heimfeld, ...
Cytotherapy 12 (2), 161-169 , 2010
17 2010
Cryopreservation of peripheral blood stem cells using a box-in-box cooling device
X Zhou, X Kang, Z Shu, H Chen, W Ding, P Du, D Yadock, C Chi Liu, ...
Biopreservation and biobanking 7 (2), 107-114 , 2009
5 2009
Electrical conductivity measurements for the ternary systems of glycerol/sodium chloride/water and ethylene glycol/sodium chloride/water and their applications in cryopreservation
HH Chen, X Zhou, Z Shu, EJ Woods, D Gao
Biopreservation and Biobanking 7 (1), 13-18 , 2009
4 2009
Cryopreservation of Hematopoietic Stem Cells with the Developed Low-cost, Reliable and Cooling Rate Semi-controlled Device: Box-in-box
Z Shu
University of Washington , 2009
  2009
A Micromachined Device Using Transient Hot-Wire Method for High Accuracy Thermal Conductivity Measurement of Semi-Rigid Materials
X Liang, W Ding, Z Shu, X Zhou, D Gao
ASME 2008 3rd Frontiers in Biomedical Devices Conference, 71-72 , 2008
  2008
A Steady-State Model of Mass Transfer for Removing Cryoprotective Agents From Cryopreserved Blood With Hollow Fiber Modules
W Ding, Z Shu, X Zhou, X Kang, D Gao
ASME 2008 3rd Frontiers in Biomedical Devices Conference, 115-116 , 2008
  2008
Development of a Controlled Rate Cooling System for Cryopreservation
H Chen, Z Shu, D Gao
ASME 2008 3rd Frontiers in Biomedical Devices Conference, 87-88 , 2008
  2008
The protective function of trehalose and egg yolk in the freeze drying of human spermatozoa
Z Shu, H Zhang, N Zhang, F Yu, J Li, L He, Z Chen, W Ji, S Yang, D Gao
  2007
The structural and cellular viability in cryopreserved rabbit carotid arteries
P Wang, Z Shu, L He, S Chen, Y Wang, XL Wang
Journal of Surgical Research 131 (2), 241-251 , 2006
17 2006
The viability, structure, and mechanical properties of cryopreserved rabbit carotid artery
P Wang, Z Shu, L He, Y Wang, X Cui, J Yu, J Lu, D Gao
Cell preservation technology 3 (2), 85-95 , 2005
8 2005
THE VESSEL STRUCTURE AND MECHANICAL PROPERTIES OF CRYOPRESERVED RABBIT CAROTIDS AFTER IN VITRO CULTURE [J]
P WANG, H LIU, Z SHU
Medical Journal of Qilu 1, 002 , 2005
1 2005
The pertinence of expression of heat shock proteins (HSPs) to the efficacy of cryopreservation in HELAs
P Wang, Z Shu, L He, X Cui, Y Wang, D Gao
CryoLetters 26 (1), 7-16 , 2005
17 2005
Double porous media model for mass transfer of hemodialyzers
W Ding, L He, G Zhao, H Zhang, Z Shu, D Gao
International Journal of Heat and Mass Transfer 47 (22), 4849-4855 , 2004
24 2004
A novel theoretical model for mass transfer of hollow fiber hemodialyzers
W Ding, L He, G Zhao, Z Shu, S Cheng, D Gao
Chinese Science Bulletin 48 (21), 2386-2390 , 2003
5 2003
Determination of cell volume during equilibrium freezing process
G Zhao, L He, P Wang, W Ding, X Xie, Z Liu, H Zhang, Z Shu, D Luo, ...
Chinese Science Bulletin 48 (15), 1551-1554 , 2003
16 2003
The influence of different thawing rates on the mechanical properties of the cryopreserved rabbit arteries
Z SHU, L HE, P WANG, W DING, D GAO
Chinese Journal of Biomedical Engineering 3, 001 , 2003
1 2003
testCryopreservation of human mucosal leukocytes
SM Hughes, Z Shu, CN Levy, AL Ferre, H Hartig, C Fang, G Lentz, ...
 

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